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Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

《农业科学与工程前沿（英文）》 2015年 第2卷 第4期   页码 318-326 doi: 10.15302/J-FASE-2015080

摘要： Garlic ( Liliaceae) has been safely used for more than 5000 years, and research on garlic extract is rapidly increasing because of its multiple biological functions. The effects of oral administration of garlic mixture (GM, water-soluble extract) on infectious bursal disease virus (IBDV)-infected specific pathogen free male white leghorn chicken were examined through histopathological, immunohistochemical, and Western blot analyses, and enzyme-linked immunosorbent assay. The results confirmed the protective effects of oral administration of 5 mg·kg BW GM (Group GM1) on bursal lesions after IBDV infection. In particular, protein expression of IBDV in the bursa decreased in Group GM1, indicating that GM administration decreased IBDV replication in the bursa. Furthermore, immunoglobulin M- and A-bearing B lymphocytes significantly increased 7 days post infection in bursae in Group GM1 ( <0.01), suggesting that the oral administration of 5 mg·kg GM offers moderate protection against B cell destruction after IBDV infection. During infection, the concentration of bursal interferon gamma (IFN-g) increased and peaked in Group GM1 earlier than in Group T (IBDV-exposed), demonstrating that GM administration prompted the production of IFN-g to protect against IBDV infection.

关键词： garlic     infectious bursal disease virus (IBDV)     antiviral effect     IgM-bearing B lymphocyte    

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as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor lymphocyte

《医学前沿（英文）》 2021年 第15卷 第5期   页码 728-739 doi: 10.1007/s11684-021-0833-x

摘要： Relapse is the main problem after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The outcome of a second allo-HSCT (HSCT2) for relapse post-HSCT has shown promising results in some previous studies. However, little is known about the efficacy of HSCT2 in patients with relapsed/refractory acute leukemia (AL) post-chemotherapy plus modified donor lymphocyte infusion (post-Chemo+m-DLI) after the first allo-HSCT (HSCT1). Therefore, we retrospectively analyzed the efficacy of HSCT2 in 28 patients with relapsed/refractory AL post-Chemo+m-DLI in our center. With a median follow-up of 918 (457–1732) days, 26 patients (92.9%) achieved complete remission, and 2 patients exhibited persistent disease. The probabilities of overall survival (OS) and disease-free survival (DFS) 1 year after HSCT2 were 25.0% and 21.4%, respectively. The cumulative incidences of nonrelapse mortality on day 100 and at 1 year post-HSCT2 were 7.1%±4.9% and 25.0%±8.4%. The cumulative incidences of relapse were 50.0%±9.8% and 53.5%±9.9% at 1 and 2 years post-HSCT2, respectively. Risk stratification prior to HSCT1 and percentage of blasts before HSCT2 were independent risk factors for OS post-HSCT2, and relapse within 6 months post-HSCT1 was an independent risk factor for DFS and relapse post-HSCT2. Our findings suggest that HSCT2 could be a salvage option for patients with relapsed AL post-Chemo+m-DLI.

关键词： second hematopoietic stem cell transplantation     acute leukemia     relapse     chemotherapy     modified donor lymphocyte infusion    

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leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directed donor lymphocyte

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

《医学前沿（英文）》 2019年 第13卷 第2期   页码 238-249 doi: 10.1007/s11684-017-0599-3

摘要： The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI) ( =24). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Recombinant human IFN-α-2b injections were subcutaneously administered 2–3 times a week for 6 months. Nine (37.5%), 6 (25.0%), and 3 (12.5%) patients became MRD-negative at 1, 2, and>2 months after the salvage IFN-α treatment, respectively. Two-year cumulative incidences of relapse and non-relapse mortality were 35.9% and 8.3%, respectively. Two-year probabilities of event-free survival, disease-free survival, and overall survival were 51.6%, 54.3%, and 68.0%, respectively. Outcomes of patients subjected to salvage IFN-α treatment after DLI were significantly better than those with persistent MRD without IFN-α treatment. Moreover, clinical outcomes were comparable between the salvage DLI and IFN-α treatment groups. Thus, salvage IFN-α treatment may help improve the outcome of patients with unsatisfactory responses to MRD-directed DLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell transplantation.

关键词： interferon-α     hematopoietic stem cell transplantation     minimal residual disease     donor lymphocyte infusion    

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大菱鲆免疫球蛋白M(IgM)单克隆抗体的制备与特性鉴定

王蔚芳,李青梅,柴书军,甘玲玲,洪磊,郭军庆,雷霁霖

《中国工程科学》 2014年 第16卷 第9期   页码 16-20

摘要：

应用细胞工程技术研制大菱鲆免疫球蛋白M(immunoglobulin M，IgM)的单克隆抗体并分析其免疫学特性。小鼠骨髓瘤细胞NS0 与经IgM免疫的BALB/C小鼠脾细胞融合，经过反复有限稀释法克隆，筛选获得4 株抗大菱鲆IgM的单克隆抗体杂交瘤细胞株，分别为B1D1、D5C2、E1B2 和F4A1。Western blot 分析表明，获得的单抗与IgM 重链区特异性结合。本研究制备的大菱鲆IgM单克隆抗体效价高、灵敏度高、特异性强，适合用于大菱鲆免疫学相关研究和生产实际应用。

关键词： 大菱鲆     免疫球蛋白M     单克隆抗体     BALB/C小鼠    

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Iterative HOEO fusion strategy: a promising tool for enhancing bearing fault feature

《机械工程前沿（英文）》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0725-z

摘要： As parameter independent yet simple techniques, the energy operator (EO) and its variants have received considerable attention in the field of bearing fault feature detection. However, the performances of these improved EO techniques are subjected to the limited number of EOs, and they cannot reflect the non-linearity of the machinery dynamic systems and affect the noise reduction. As a result, the fault-related transients strengthened by these improved EO techniques are still subject to contamination of strong noises. To address these issues, this paper presents a novel EO fusion strategy for enhancing the bearing fault feature nonlinearly and effectively. Specifically, the proposed strategy is conducted through the following three steps. First, a multi-dimensional information matrix (MDIM) is constructed by performing the higher order energy operator (HOEO) on the analysis signal iteratively. MDIM is regarded as the fusion source of the proposed strategy with the properties of improving the signal-to-interference ratio and suppressing the noise in the low-frequency region. Second, an enhanced manifold learning algorithm is performed on the normalized MDIM to extract the intrinsic manifolds correlated with the fault-related impulses. Third, the intrinsic manifolds are weighted to recover the fault-related transients. Simulation studies and experimental verifications confirm that the proposed strategy is more effective for enhancing the bearing fault feature than the existing methods, including HOEOs, the weighting HOEO fusion, the fast Kurtogram, and the empirical mode decomposition.

关键词： higher order energy operator     fault diagnosis     manifold learning     rolling element bearing     information fusion    

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New analysis model for rotor-bearing systems based on plate theory

Zhinan ZHANG, Mingdong ZHOU, Weimin DING, Huifang MA

《机械工程前沿（英文）》 2019年 第14卷 第4期   页码 461-473 doi: 10.1007/s11465-019-0525-2

摘要： The purpose of this work is to develop a new analysis model for angular-contact, ball-bearing systems on the basis of plate theory instead of commonly known approaches that utilize spring elements. Axial and radial stiffness on an annular plate are developed based on plate, Timoshenko beam, and plasticity theories. The model is developed using theoretical and inductive methods and validated through a numerical simulation with the finite element method. The new analysis model is suitable for static and modal analyses of rotor-bearing systems. Numerical examples are presented to reveal the effectiveness and applicability of the proposed approach.

关键词： rotor-bearing system     rolling element bearing     plate theory     finite element analysis    

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API-based assessment on urban air environment bearing capability in China

Jinnan WANG,Jing ZHANG,Hongqiang JIANG,Yaling LU

《环境科学与工程前沿（英文）》 2015年 第9卷 第6期   页码 1049-1055 doi: 10.1007/s11783-014-0662-0

摘要： Given the complexity and time-consuming of the conventional environmental capacity based assessment on air environment carrying capacity; a new method for assessing urban air environment carrying capacity based on air pollution index (API) is presented. By using this new method, the air environmental bearing capability of 333 cities at the prefecture level and above is assessed. The results show that of the 333 cities 9.6% is of high bearing capability, 34.5% relatively high bearing capability, 52.6% medium bearing capability, 2.7% low capability, and 0.6% is of weak bearing capability; in terms of regional distribution, the western region is of relatively high air environment bearing capability, followed by north-eastern and eastern regions, and the ambient air quality in the middle region is quite poor; among the 12 urban agglomerations in key regions, Pearl River delta, west side of Taiwan Strait and Chengdu-Chongqing agglomerations are of relatively high carrying capacity while other agglomerations are of medium bearing capability. The assessment results imply that the existing air quality standard (GB3095-1996) is quite unsound.

关键词： air pollution index (API)     air environment bearing capability     key city     assessment method    

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The convexity about ultimate bearing hypersurfaces of structures

Chengxi GUO,Tingting GUO

《结构与土木工程前沿（英文）》 2016年 第10卷 第4期   页码 456-461 doi: 10.1007/s11709-016-0334-1

摘要： The relationship between the convexity on the ultimate bearing surface of a structure and the second-order effects of loads is discussed. All of generalized non-overload forces acted on a structure forms a convex set when ignoring the second-order effects (coupling effects between the generalized forces). It is true also when the Hessian matrix composed of the second-order partial derivatives on the hypersurface about the ultimate bearing of the structure is negative definite. The outward convexity is kept when the surface is expressed by certain dimensionless parameters. A series of properties based on the convexity are pointed out. Some applications in the analysis of bearing capacity of structures were illustrated with examples. The study shows that an evaluation about the bearing capacity state of a complex structure can be made on the basis of several points on the surface of the ultimate bearing of the structure.

关键词： service     limit load     ultimate bearing surface     convexity     generalized force     generalized displacement     frame structure    

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Foundations bearing capacity subjected to seepage by the kinematic approach of the limit analysis

Mehdi VEISKARAMI, Ghasem HABIBAGAHI

《结构与土木工程前沿（英文）》 2013年 第7卷 第4期   页码 446-455 doi: 10.1007/s11709-013-0227-5

摘要： An estimate of the ultimate load on foundations on soil layers subject to groundwater flow has been presented. The kinematic approach of the limit analysis was employed to find the upper-bound limit of the bearing capacity. Both smooth and rough base strip foundations were considered associated with different collapse patterns. Presence of the groundwater flow leads to a non-symmetric collapse pattern, i.e., a weak side and a strong side in two-sided collapse patterns, depending on the direction of the flow. It was found that the bearing capacity has a decreasing trend with increase in the groundwater flow gradient and hence, a reduction factor has been introduced to the third term in the bearing capacity equation as a function of the flow gradient.

关键词： foundation     bearing capacity     limit analysis     numerical computation     plasticity     seepage    

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Undrained seismic bearing capacity of strip footing adjacent to a heterogeneous excavation

《结构与土木工程前沿（英文）》 2023年 第17卷 第4期   页码 566-583 doi: 10.1007/s11709-023-0905-x

摘要： The analysis of the bearing capacity of strip footings sited near an excavation is critical in geotechnics. In this study, the effects of the geometrical features of the excavation and the soil strength properties on the seismic bearing capacity of a strip footing resting on an excavation were evaluated using the lower and upper bounds of the finite element limit analysis method. The effects of the setback distance ratio (L/B), excavation height ratio (H/B), soil strength heterogeneity (kB/cu), and horizontal earthquake coefficient (kh) were analyzed. Design charts and tables were produced to clarify the relationship between the undrained seismic bearing capacity and the selected parameters.

关键词： excavation     finite element limit analysis     heterogeneous soil     strip footing     undrained bearing capacity    

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Influence of the Mechanical Seals on the Dynamic Performance of Rotor–Bearing Systems

XU Hua, ZHU Jun

《机械工程前沿（英文）》 2006年 第1卷 第1期   页码 96-100 doi: 10.1007/s11465-005-0008-5

摘要：

In this paper, to consider the effects of mechanical seals, a lumped-mass model and the transfer matrix method are used to establish the equations for the dynamics performance of rotor bearing system. The general inverted iteration method is also used to solve the eigenvalue problem of these equations. To check the response of the rotor bearing system under unbalance motivation, the Gauss method is used to calculate the dynamic response of the constrained vibration. The results, based on the dynamic properties calculation of a typical mechanical spiral seal, such as stiffness coefficients and damping coefficients, exert the influence of the mechanical seal on the rotor bearing system of the high-speed machinery. Meanwhile, some structure parameters that may affect the dynamic performance and forced vibration under unbalance motivation of the rotor bearing system considering mechanical seals are analyzed in the paper. The analysis results show that the mechanical seal more or less has effects on the rotor bearing system. The mechanical seal has much more effects on the flexible rotor bearing system than on the rigid one. For instance, in a certain case, if the effects of the mechanical seal were taken into account, the system s critical speed may increase by 70 80%.

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Ultimate bearing capacity of strip footing resting on clay soil mixed with tire-derived aggregates

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 1016-1024 doi: 10.1007/s11709-021-0751-7

摘要： This study investigated the use of recycled tire-derived aggregate (TDA) mixed with kaolin as a method of increasing the ultimate bearing capacity ( UBC) of a strip footing. Thirteen 1g physical modeling tests were prepared in a rigid box of 0.6 m × 0.9 m in plan and 0.6 m in height. During sample preparation, 0%, 20%, 40%, or 60% (by weight) of powdery, shredded, small-sized granular (G 1–4 mm) or large-sized granular (G 5–8 mm) TDA was mixed with the kaolin. A strip footing was then placed on the stabilized kaolin and was caused to fail under stress-controlled conditions to determine the UBC. A rigorous 3D finite element analysis was developed in Optum G-3 to determine the UBC values based on the experimental test results. The experimental results showed that, except for the 20% powdery TDA, the TDA showed an increase in the UBC of the strip footing. When kaolin mixed with 20% G (5–8 mm), the UBC showed a threefold increase over that for the unreinforced case. The test with 20% G (1–4 mm) recorded the highest subgrade modulus. It was observed that the UBC calculated using finite element modeling overestimated the experimental UBC by an average of 9%.

关键词： kaolin     physical modeling tests     stabilization     numerical modeling    

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Temperature control of transfer roller’s bearing based on finite element analysis

Peng ZHANG, Yourong LI, Han XIAO

《机械工程前沿（英文）》 2009年 第4卷 第2期   页码 215-218 doi: 10.1007/s11465-009-0026-9

摘要： After a heat preservation cover is installed on the main rolling line, the heat dissipation environment of the transfer roller working on the heat preservation cover is changed. To ensure the normal production, a reasonable working jet capacity of the roller neck is derived. First, a globe model of the transfer roller is built for finite element analysis. Second, the sub-model of the fixed end bearing is built and the boundary condition of the sub-model is supplied by the results of the globe model. The analysis result of the sub-model shows that the temperature of the transfer roller bearing exceeds 85°C a rolling periodicity later. With finite element analysis, the heat flux is obtained and the minimum working jet capacity is derived.

关键词： transfer roller bearing     finite element analysis     sub-model     temperature control    

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Liquefaction and impurity separation of oxygen-bearing coal-bed methane

Qiuying LI, Yonglin JU, Li WANG,

《能源前沿（英文）》 2010年 第4卷 第3期   页码 319-325 doi: 10.1007/s11708-010-0115-9

摘要： Coal-bed methane (CBM) is a type of clean energy. However, most oxygen-bearing CBM have not yet to be utilized due to limited techniques, and when utilized, the discharged gas leads to resource wastage and environment pollution. In this paper, a liquefaction process is proposed and designed for the specified oxygen-bearing CBM obtained from the Daqing Qingshen gas field. The distillation column is employed to separate the oxygen and nitrogen components present in the CBM. HYSYS software is adopted to simulate the process, and the results reveal that the energy consumption of the whole liquefaction process is low. Moreover, oxygen and nitrogen are nearly removed completely, achieving a high-purity liquefied natural gas product with a high methane recovery rate. The applicability and safety of the liquefaction process are also analyzed. The simulation results can offer references for the separation of the oxygen component from CBM.

关键词： coal bed methane     oxygen-bearing     liquefaction     distillation    

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An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 362-367 doi: 10.1007/s11684-014-0363-x

摘要：

This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patients from 19 provinces and cities treated with TCM from 2004 to 2013 was collected. Changes in the indexes of CD4 counts (≤200, 201–350, 351–500 and>500 cells/mm3) at five time points (0, 12, 36, 60 and 84 months) and different treatments [TCM and TCM plus antiretroviral therapy (ART)] were compared. Repeated measures test indicated no interaction between group and time (P>0.05). Degrees of increasing and decreasing CD4 count of the two groups at four different frames were statistically significant compared with the baseline. The CD4 count between the two groups was not statistically significant. For CD4 count of≤200 cells/mm3, the mean CD4 count changes were 21 and 28 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 201–350 cells/mm3, the mean CD4 count changes were 6 and 25 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 351–500 cells/mm3, the mean CD4 count changes were -13 and -7 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of>500 cells/mm3, the mean CD4 count changes were -34 and -17 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. Long-term use of TCM could maintain or slow the pace of declining CD4 counts in patients with HIV/AIDS, and may achieve lasting effectiveness.

关键词： AIDS     HIV     CD4     traditional Chinese medicine     linear models    

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标题 作者 时间 类型 操作

Oral administration of

Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG

期刊论文

as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor lymphocyte

期刊论文

leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directed donor lymphocyte

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

期刊论文

大菱鲆免疫球蛋白M(IgM)单克隆抗体的制备与特性鉴定

王蔚芳,李青梅,柴书军,甘玲玲,洪磊,郭军庆,雷霁霖

期刊论文

Iterative HOEO fusion strategy: a promising tool for enhancing bearing fault feature

期刊论文

New analysis model for rotor-bearing systems based on plate theory

Zhinan ZHANG, Mingdong ZHOU, Weimin DING, Huifang MA

期刊论文

API-based assessment on urban air environment bearing capability in China

Jinnan WANG,Jing ZHANG,Hongqiang JIANG,Yaling LU

期刊论文

The convexity about ultimate bearing hypersurfaces of structures

Chengxi GUO,Tingting GUO

期刊论文

Foundations bearing capacity subjected to seepage by the kinematic approach of the limit analysis

Mehdi VEISKARAMI, Ghasem HABIBAGAHI

期刊论文

Undrained seismic bearing capacity of strip footing adjacent to a heterogeneous excavation

期刊论文

Influence of the Mechanical Seals on the Dynamic Performance of Rotor–Bearing Systems

XU Hua, ZHU Jun

期刊论文

Ultimate bearing capacity of strip footing resting on clay soil mixed with tire-derived aggregates

期刊论文

Temperature control of transfer roller’s bearing based on finite element analysis

Peng ZHANG, Yourong LI, Han XIAO

期刊论文

Liquefaction and impurity separation of oxygen-bearing coal-bed methane

Qiuying LI, Yonglin JU, Li WANG,

期刊论文

An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients

null

期刊论文